Endocrine Abstracts

Objectives: Detection rate of thyroid nodules is increasing with use of new imaging modalities, like 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). To avoid unnecessary operations, differentiating between benign and malignant 18F-FDG PET/CT-positive thyroid nodules is essential. Many authorities recommend fine needle aspiration biopsy (FNAB) for exclusion of malignancy in thyroid nodules. Although FNAB is a simple, easily performed proc...

Aim: FGF-21, is a member of the FGF family that is involved in biological processes such as embryonic development, cellular growth, morphogenesis, tissue repair, tumor growth and invasion, with mitogenic and cellular vital activity activity in the cytogenetic localization of 19q13.33. Breast cancer is the fatal disease most commonly seen in women and increasing in frequency and the relationship between hormones secreted from adipose tissue and some cancers has been shown in re...

PurposeInferior petrosal sinus sampling (IPSS) is the gold standard test for the differentiation of pituitary Cushing disease from the ectopic ACTH syndrome (EAS). The measurement of prolactin during IPSS can be helpful to improve the accuracy of the procedure. We aimed to evaluate the effect of measuring prolactin levels as a predictor for the accuracy of IPSS procedure and evaluate its’ impact on the lateralization of adenoma.<p class="abstext...

ObjectivesPolycystic ovary syndrome (PCOS) is the most common reproductive disorder that onsets peripubertally and increases morbidity by affecting quality of life. Insulin like peptide 5 (INSL5) is a relaxine/insulin family member gut-peptide hormone that is expressed by various tissues including the hypothalamus, pituitary and ovary. In the present study, we aimed to characterize serum INSL5 levels in PCOS women and determine association of circulating...

Background: In addition to glucose-lowering effects, Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2i) are the preferred treatment of choice in patients with heart failure due to their diuretic effects through glucosuria and natriuresis. However, there is limited data about urinary symptoms associated with SGLT2i use.Objectives: Low urinary tract symptoms such as increased urinary frequency, urgency, or incontinence due to SGLT2i use are not described i...

Introduction: Atypical parathyroid tumour (APT) is a rare cause of primary hyperparathyroidism (PHPT) with a frequency of 1.2-1.3%. APT is a lesion with suspicious clinical and histological features of malignancy which does not completely respect the World Health Organization (WHO) criteria for diagnosis of Parathyroid Carcinoma (PC). There is a well-known association with PHT and medullary thyroid carcinoma for multiple endocrine neoplasia. However, concurrence of thyroid pap...

Background: Obesity is one of the most critical problems nowadays, its frequency and consequences. Since the risk of morbidity and mortality increases in obese individuals, lifestyle changes, pharmacotherapy, and bariatric surgery (BS) methods are used for treatment. BS is generally considered the most effective method to treat morbid obesity. However, it is known that thyroid function has a role in weight regulation, the effect of preoperative thyroid function on weight loss ...

Introduction: The only curative treatment of primary hyperparathyroidism (pHPT) is surgery. Accurate pre-operative localization of abnormal parathyroid glands is an essential prerequisite to reduce the complication risk associated with surgery. We aimed to determine the diagnostic value of jugular venous sampling (JVS) in cases of pHPT in which the location of parathyroid adenomas could not be determined through various preoperative imaging studies.Metho...

Aim: Sleep disturbances are widespread and closely associated with pituitary diseases, even those under long-term therapeutic management. The aim of this study was to investigate sleep quality, depression, anxiety, and physical activity in patients with non-functioning pituitary adenoma (NFPA) and determine the factors that might be associated with decreased quality of sleep.Method: Eighty-two patients with NFPAs and 82 age- and gender-matched control su...

Introduction: Insulinoma is the most common functional pancreatic neuroendocrine tumor (PanNET), accounting for more than 50% of all cases. Diagnosis of insulinomas may be challenging. In this study, we aim to discuss the clinicopathological features and long-term follow-up results of insulinoma cases followed up in our clinic.Material and Methods: It is a descriptive and retrospective study of 13 insulinoma cases diagnosed over 10 years. All data of the...